Riscover Hereditary Cancer

Riscover Hereditary Cancer

Discover your risk for hereditary cancer.

If you discover your risk, you can change your future.

When cancer runs in your family, the Riscover® Hereditary Cancer Test can help you understand your risk for certain types of cancer and ensure you’re taking all the right steps to stay healthy. It can also help your family members learn about their own risk for cancer.


Learn more about hereditary cancer testing

Knowing matters

Knowing your risk for hereditary cancer empowers you to take steps for early detection and prevention. These steps are a personal choice based on genetic results and family history, and don’t look the same for everyone.

When a risk for hereditary cancer is discovered through genetic testing, screening tests and preventive steps are often covered by insurance.

Testing can identify genetic risk for more than a dozen types of cancer, and cancer risks can come in different combinations.

Risk management options

Colorectal cancer
  • Earlier and more frequent colonoscopies
  • Preventative medication like aspirin
  • Risk-reducing surgery

Breast and ovarian cancer
  • Earlier and more frequent mammograms
  • Breast MRI screening
  • Preventative medication like tamoxifen or birth control pills
  • Risk-reducing surgery

It’s not just about you

If you have a hereditary cancer gene variant, your parents, siblings, and children have a 1 in 2 chance to have it too. Discovering your risk can help your whole family change their futures.

How is cancer inherited?

How does the testing process work?

Health plan authorization

We contact your health plan to request coverage for genetic testing. This process can take up to a month to complete. Some health plans require additional steps before testing.


Your DNA is tested by the lab, and results are sent to your healthcare provider. Testing takes about two weeks after health plan authorization.

Test result consultation

Along with your healthcare provider, Progenity’s genetic counselors are available to help you understand your results and answer any questions.

What do the results mean?

Positive (abnormal)
A positive result means that the test found a cancer gene variant that makes your risk for cancer higher than most people’s risk. It doesn’t mean that you’ll develop cancer. Knowing your risk helps you take steps for prevention or early diagnosis.

Negative (normal)
Negative results mean the test didn’t find any cancer gene variants that would increase your risk for cancer. Results are highly accurate, but no test is perfect. This test can only detect risk related to the genes included in the test.

Variant of Uncertain Significance (VUS)
Sometimes, medical researchers need to learn more about a gene variant before calling it positive or negative. These are called Variants of Uncertain Significance, or VUS, because we don’t know if they are associated with an increased risk of cancer or not. Today, VUS results are common. As researchers learn more over time, a VUS result may be updated to a positive or negative result. If this happens, we’ll tell your healthcare provider.

After testing, your healthcare provider will work with you to develop a risk management plan based on your results and medical history.

Frequently asked questions

The Riscover Hereditary Cancer Test analyzes up to 31 genes related to inherited cancer risk. Expert medical guidelines support testing of these genes because there is scientific evidence that variants in these genes can increase risk for certain cancers.

Some gene variants can cause a very high risk of cancer, while others cause a moderately increased risk. The genes that are tested may vary based on your healthcare provider's recommendation and your family history of cancer.

Risk matters. Because everyone deserves the chance to change their future.

Up to 1 in 4 patients have a family history consistent with hereditary cancer and meet criteria for genetic testing.1,2 Help your patients get the information, testing, and care that they need. Cancer prevention and early detection starts here.

If you know their risk, you can change their future. Testing for hereditary cancer risk is the standard of care for patients with a relevant family history.3

Guideline driven testing. Because actionable results matter.

Cancer family histories can be complicated. Simplify your workflow with one test designed to offer a thorough and clinically appropriate assessment of inherited cancer risk.

Carefully curated gene content

Many genes and syndromes have overlapping cancer risks, so clinical history alone often doesn’t pinpoint a single gene to investigate. The Riscover® Hereditary Cancer Test analyzes up to 31 genes that have known associations with cancer risk.

Variant classification that exceeds industry standards

  • CURATED by a highly qualified team of genetic experts, in accordance with ACMG professional guidelines.
  • CONFIRMED by an independent method to ensure quality control.
  • REPORTED to the NCBI ClinVar database to help advance the science of cancer risk analysis.

Genes and cancer impact

Insight to cancer risks drives decisions4,5

The Riscover Hereditary Cancer Test analyzes up to 31 genes that have known associations with cancer risk.

Click here for a list of clinical and management summaries.


Fast facts: Riscover Hereditary Cancer

Test Includes
Specimen Type
Turnaround Time
Reported Variants
Evaluates up to 31 genes associated with increased risk for breast, ovarian, colorectal, endometrial, pancreatic, and other cancers
Whole blood, buccal swab, or mouthwash specimens accepted
Results in 2 – 3 weeks (after prior authorization)
Pathogenic; Likely pathogenic; VUS

Why Progenity? We make it easy.

From start to finish, our team is committed to making your life easier. We’ll work with you to implement a practical program of genetic testing, tailored to the needs of your practice and your patients.

Expert clinical support for providers & patients

Our team is here for you. A world-class team of genetic counselors and experienced laboratory directors is on call to support physicians and discuss results with patients.

Proactive notification of positive results

Never miss a positive result. Our staff reviews each positive result and personally contacts your office. Our team of genetic counselors is always available to answer any questions.

Personalized client service at every step

Where you’re a name, not a number. Your responsive Progenity account manager is available locally, and the Progenity Client Services team is just a phone call away.


  1. DeFrancesco et al. Hereditary Cancer Risk Assessment and Genetic Testing in the Community Practice Setting. Obstetrics & Gynecology 2018 - published online before print November 2018.
  2. Progenity, Inc. Data on file.
  3. Hereditary cancer syndromes and risk assessment. Committee Opinion No. 634. American College of Obstetricians and Gynecologists. Obstet Gynecol 2015; 125:1538-43
  4. National Comprehensive Cancer Network. Genetic/Familial High-Risk Assessment: Colorectal (Version 1.2018). Available at nccn.org
  5. National Comprehensive Cancer Network. Genetic/Familial High-Risk Assessment: Breast and Ovarian (Version 3.2019). Available at nccn.org