Riscover® Hereditary Cancer

Riscover<sup>®</sup>  Hereditary Cancer

Test for hereditary cancer risk.

Knowing your risk gives you options for early detection and prevention.

There are better health outcomes if you know early.

Protect your whole family.

If you have a hereditary cancer gene variant, your parents, siblings, and children have a 1 in 2 chance of having it, too.

If you discover your risk, you can change your future.

When cancer runs in your family, hereditary cancer testing can help you understand your risk, so you can take steps to stay healthy.

Knowing your risk for hereditary cancer empowers you to take steps for early detection and prevention. These steps are a personal choice based on genetic test results and family history. When risk for hereditary cancer is discovered through genetic testing, screening tests and preventative steps are often covered by insurance.


Learn more about hereditary cancer testing.

If you know, you can make a plan.

Knowing your risk can help you prepare for life in these important ways:

Colorectal cancer risk management options
  • Earlier and more frequent colonoscopies
  • Preventative medication like aspirin
  • Risk-reducing surgery

Breast and ovarian cancer risk management options
  • Earlier and more frequent mammograms
  • Breast MRI screening
  • Preventative medication like tamoxifen or birth control pills
  • Risk-reducing surgery

It’s not just about you.

If you have a hereditary cancer gene variant, your parents, siblings, and children have a 1 in 2 chance to have it too. Discovering your risk can give your whole family important information about their health.

How is cancer inherited?

Getting tested is simple and safe.

Visit your healthcare provider

Ask your doctor if this test is right for you.

Collect your sample

Your healthcare provider will take a blood sample and send it to the Progenity laboratory.

Health plan authorization

We contact your health plan to request coverage for genetic testing. This process can take up to a month to complete. Some health plans require additional steps before testing.

If your health plan approves coverage, you'll be responsible for co-pay and deductibles, like any other healthcare service. If your health plan denies coverage, we'll call you to review your options.

Receive your results

Your test results will be ready in about 2 weeks after health plan authorization. You will be notified when they are ready.

Review your next steps

Get complimentary access to Progenity Genetic Counselors to help you and your healthcare provider plan your next steps.

What do my results mean?

The Riscover Hereditary Cancer Test looks for gene variants associated with cancer risk. Testing can identify genetic risk for more than a dozen types of cancer, and cancer risks can come in different combinations.

Positive (abnormal)
A positive result means that the test found a cancer gene variant that makes your risk for cancer higher than most people’s risk. It doesn’t mean that you’ll develop cancer. Knowing your risk helps you take steps for prevention or early diagnosis.

Negative (normal)
Negative results mean the test didn’t find any cancer gene variants that would increase your risk for cancer. Results are highly accurate, but no test is perfect. This test can only detect risk related to the genes included in the test.

Variant of Uncertain Significance (VUS)
Sometimes, medical researchers need to learn more about a gene variant before calling it positive or negative. These are called Variants of Uncertain Significance, or VUS, because we don’t know if they are associated with an increased risk of cancer or not. Today, VUS results are common. As researchers learn more over time, a VUS result may be updated to a positive or negative result. If this happens, we’ll tell your healthcare provider.

Frequently asked questions

Guideline driven testing.

Because actionable results matter

Carefully curated gene content.

Analyzing up to 31 genes

Variant classification that exceeds industry standards.

In accordance with ACMG professional guidelines

Risk matters. Because everyone deserves the chance to change their future.

Up to 1 in 4 patients have a family history consistent with hereditary cancer and meet criteria for genetic testing.1,2 Help your patients get the information, testing, and care that they need. Cancer prevention and early detection starts here.

If you know their risk, you can change their future. Testing for hereditary cancer risk is the standard of care for patients with a relevant family history.3

Guideline driven testing. Because actionable results matter.

Cancer family histories can be complicated. Simplify your workflow with one test designed to offer a thorough and clinically appropriate assessment of inherited cancer risk.

Carefully curated gene content

Many genes and syndromes have overlapping cancer risks, so clinical history alone often doesn’t pinpoint a single gene to investigate. The Riscover® Hereditary Cancer Test analyzes up to 31 genes that have known associations with cancer risk.

Variant classification that exceeds industry standards

  • CURATED by a highly qualified team of genetic experts, in accordance with ACMG professional guidelines.
  • CONFIRMED by an independent method to ensure quality control.
  • REPORTED to the NCBI ClinVar database to help advance the science of cancer risk analysis.

Genes and cancer impact

Insight to cancer risks drives decisions4,5

The Riscover Hereditary Cancer Test analyzes up to 31 genes that have known associations with cancer risk.

Download a list of clinical and management summaries.



Test Includes
Specimen Type
Turnaround Time
Reported Variants
Evaluates up to 31 genes associated with increased risk for breast, ovarian, colorectal, endometrial, pancreatic, and other cancers
Whole blood, buccal swab, or mouthwash specimens accepted
Results in 2 – 3 weeks (after prior authorization)
Pathogenic; Likely pathogenic; VUS

Why Progenity? We make it easy.

From start to finish, our team is committed to making your life easier. We’ll work with you to implement a practical program of genetic testing, tailored to the needs of your practice and your patients.

Expert clinical support for providers & patients

Our team is here for you. A world-class team of genetic counselors and experienced laboratory directors is on call to support physicians and discuss results with patients.

Proactive notification of positive results

Never miss a positive result. Our staff reviews each positive result and personally contacts your office. Our team of genetic counselors is always available to answer any questions.

Personalized client service at every step

Where you’re a name, not a number. Your responsive Progenity account manager is available locally, and the Progenity Client Services team is just a phone call away.


  1. DeFrancesco et al. Hereditary Cancer Risk Assessment and Genetic Testing in the Community Practice Setting. Obstetrics & Gynecology 2018 - published online before print November 2018.
  2. Progenity, Inc. Data on file.
  3. Hereditary cancer syndromes and risk assessment. Committee Opinion No. 634. American College of Obstetricians and Gynecologists. Obstet Gynecol 2015; 125:1538-43
  4. National Comprehensive Cancer Network. Genetic/Familial High-Risk Assessment: Colorectal (Version 1.2018). Available at nccn.org
  5. National Comprehensive Cancer Network. Genetic/Familial High-Risk Assessment: Breast and Ovarian (Version 3.2019). Available at nccn.org